Response Pathways A Systems Approach to Mapping DNA Damage
نویسنده
چکیده
http://www.sciencemag.org/cgi/content/full/312/5776/1054 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/312/5776/1054/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/312/5776/1054#related-content http://www.sciencemag.org/cgi/content/full/312/5776/1054#otherarticles , 19 of which can be accessed for free: cites 27 articles This article 23 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/312/5776/1054#otherarticles 11 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/cell_biol Cell Biology : subject collections This article appears in the following
منابع مشابه
Supporting Online Material for: A Systems Approach to Mapping DNA Damage Response Pathways
Supporting Online Material for: A Systems Approach to Mapping DNA Damage Response Pathways Christopher T. Workman, H. Craig Mak, Scott McCuine, Jean-Bosco Tagne, Maya Agarwal, Owen Ozier, Thomas J. Begley, Leona D. Samson, and Trey Ideker 1 University of California San Diego, La Jolla, CA 92093 2 Whitehead Institute for Biomedical Research, Cambridge, MA 02139 3 University of Albany-State Univ...
متن کاملThe Role of chk2 in Response to DNA Damage in Cancer Cells
Accumulation of gene changes and chromosomal instability in response to cellular DNA damage lead to cancer. DNA damage induces cell cycle checkpoints pathways. Checkpoints regulate DNA replication and cell cycle progression, chromatin restructuring, and apoptosis. Checkpoint kinase 2 (chk2) is activated in response to DNA lesions. ATM phosphorylate chk2. The activated Chk2 kinase can phosphoryl...
متن کاملEpigenetic: A missing paradigm in cellular and molecular pathways of sulfur mustard lung: a prospective and comparative study
Sulfur mustard (SM, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes DNA alkylation, protein modification and membrane damage. SM can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function. Epigenetic regulation of gene expression is a growing research topic and is ...
متن کاملO-35: Over-Expression of XRCC1 As Potential Biomarker for Poor Prognosis in Human Preimplantation Embryos: Selection by Study of 84 Genes Involved in DNA Damage Signaling Pathways
Background: Chromosome abnormalities are associated with poor morphology and development in human preimplantation embryos, all together lead to poor outcomes. This study aimed to explore altered expression of DNA damage pathways in “poor morphological and development embryos with sever aneuploidies”. Materials and Methods: Surplus day-4 embryos of PGD cases were pooled in two groups: Poor progn...
متن کاملEffects of low dose radiation on the expression of proteins related to DNA repair requiring Caveolin-1 in human mammary epithelial cells
Background: Radiotherapy is an effective and important therapeutic method for breast cancer, but at the same time it has a radiation-induced bystander effect on normal tissue around the tumor. Repair of double-strand breaks (DSBs) by normal cells can reduce the extent of damage caused by this effect. Caveolin-1 (Cav-1) is an important regulatory molecule in cell signal transduction. However, th...
متن کاملResponse Protein Ribonucleotide Reductase 1 Autophagy-Dependent Regulation of the DNA Damage
Protein synthesis and degradation are posttranscriptional pathways used by cells to regulate protein levels. We have developed a systems biology approach to identify targets of posttranscriptional regulation and we have employed this system in Saccharomyces cerevisiae to study the DNA damage response. We present evidence that 50% to 75% of the transcripts induced by alkylation damage are regula...
متن کامل